Course: Downstream Processing (1510-431)

Persons:

• Prof.Dr.-I Rudolf Hausmann (verantwortlich)
• Dr. rer. nat. Karin Moß (begleitend)
• Dr.-Ing. Marius Henkel (begleitend)

Type of Course:

lecture with seminar and practicals

In-Class Hours Per Week:

6

Contents:

The module comprises a lecture, a seminar and a lab hands-on training in which the purification of bioproducts from the original state as a component of a fermentation broth through progressive purification steps to a final product are the topic.
Outline:
1) Introduction
2) Solid-Liquid Separation
3) Cell Disruption
4) Precipitation and Crystallization
5) Preparative Chromatography
6) Membrane Separation
7) Extraction
8) Refolding
9) Summary

Literature:

R. G. Harrison, P. Todd, S. R. Rudge, D. P. Petrides (2003): Bioseparations Science and Engineering, Oxford University Press

Location:

Hohenheim

Remarks:

Attendance and active participation in the laboratory course is mandatory. Due to the fact that every group has full responsibility for performing their own experiment, in-lab times will be flexible but require reasonable planning on the main experimental days.

Module:

• 1510-430 Integrated Bioprocess Engineering – Bioseparation Process Science (Downstream Processing) (compulsory)

eLearning:

Course in ILIAS